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Gullian Barre Syndrome ( AIDP )

Gullian Barre Syndrome ( AIDP )

Definition
Guillain-Barre syndrome is a postinfectious polyneuropathy involving mainly motor but sometimes also sensory and autonomic nerves. Guillain-Barré syndrome is an acute demyelinating disorder of the peripheral nervous system that results from an aberrant immune response directed at peripheral nervesThe pathogenesis of GBS is believed to be an abnormal immune response to an antecedent event, most commonly an infection. (Nelson Textbook of …

Vitamin D deficiency and Chronic muscle pain

Vitamin D deficiency and Chronic muscle pain

Introduction:
Chronic widespread muscle pain is very prevalent in general population. Many studies have been done to identify its reason and hypovitaminosis d is one of the major cause of chronic muscle pain. Deficiency of vitamin d causes not only muscle pain but also ricktets in children, osteomalacia.
It is a fat soluble vitamin which helps in absorption and metabolism of calcium …

Delayed wound healing in Diabetes Mellitus

Delayed wound healing in Diabetes Mellitus

Diabetes Mellitus (DM) is a chronic disorder of glucose metabolism with hyperglycemia triggered by conditions associated with a relative or absolute insulin deficiency. Insulin is an anabolic hormone with profound effects on the metabolism of carbohydrate, fat and protein. Less severe hyperglycemia is called Impaired Glucose Tolerance (IGT) which is associated with an increased risk of developing diabetes in future. …

Uterine leiomyoma or Fibroid

Uterine leiomyoma or Fibroid

Definition: Most common benign neoplasm of female genital tract composed of smooth muscle and connective tissue that is hormonally responsive (Growth ↑ in pregnancy and ↓ after menopause).
Gross pathology:

Discrete, round, firm, irregularly lobulated and often multiple.
Enlarged uterus
Smooth and white cut surface with whorled appearance
False capsule: pinkish color
Center of tumor is least vascular and likely to degenerate

Risk factors:

Nulliparity
Obesity
Hyperestrogenic state
Black race

Types:

Types
Features

Intramural
Within uterine …

Acute Rheumatic Fever in Children

Acute Rheumatic Fever in Children

Definition: Immunologic sequel of a previous group A beta hemolytic streptococcal infection of pharynx (not of the skin according to some researches). The rheumatogenic strains are M 1, 3, 5, 6, 14, 18, 19 and 24.
Pathogenesis:

Molecular mimicry
Affects brain, heart, joints, and skin
In genetically vulnerable host

Pathogenesis and morphology: Rheumatic fever and Rheumatic heart disease
Epidemiology:

Peak incidence: 5-15 years
Follows pharyngitis by 1 to …

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