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Gullian Barre Syndrome – Post-infectious demyelinating polyneuropathy

Gullian Barre Syndrome – Post-infectious demyelinating polyneuropathy

Definition
Guillain-Barre syndrome is a postinfectious polyneuropathy involving mainly motor but sometimes also sensory and autonomic nerves. Guillain-Barré syndrome is an acute demyelinating disorder of the peripheral nervous system that results from an aberrant immune response directed at peripheral nervesThe pathogenesis of GBS is believed to be an abnormal immune response to an antecedent event, most commonly an infection. (Nelson Textbook of …

Maternal Rhesus Isoimmunization : Rh incompatibility

Maternal Rhesus Isoimmunization : Rh incompatibility

Alloimmunization (Isoimmunisation) is defined as the antibody response to foreign antigen derived from different individual of the same species. Rh alloimmunization refers to the development antibodies to Rh D antigen. Antibodies may be produced to Rh antigens C,c,D,E, or e but only D is strongly immunogenic.
PATHOPHYSIOLOGY

1st Rh+ve pregnancy: Rh negative mother bearing Rh positive fetus
Feto-maternal bleed: Abortion, Amniocentesis, Antepartum hemorrhage, …

GFR Calculations- Accepted formula

GFR Calculations- Accepted formula

Estimated values
A number of formulae have been devised to estimate GFR or Ccr values on the basis of serum creatinine levels.

Estimated creatinine clearance rate (eCCr) using Cockcroft-Gault formula
A commonly used surrogate marker for estimate of creatinine clearance is the Cockcroft-Gault formula, which in turn estimates GFR: It is named after the scientists who first published the formula, and it …

Tetrabenazine – A forgotten drug for Dystonia

Tetrabenazine – A forgotten drug for Dystonia

An 8 year old girl presented to the pediatric ER with complaints of fever for 1 week, altered sensorium for 5 days and multiple episodes of generalized tonic clonic seizures for 4 days. She was a known case of neurocysticercosis for the last 6 years, had been under antiepileptic therapy (carbamazepine and phenytoin) for 3 years and was discontinued after …

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