Major Archive

Cancer medicine in the era of Next Generation Sequencing: Solving the Puzzle

Editor Medicine February 4, 2015

Cancer as a disease still remains one of the most complex human illness with high degree of morbidity and mortality across the globe. The involvement of multiple risk factors (genetics, hereditary, environmental etc) further adds a huge challenge in understanding the cancer puzzle even ...Read More

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Dental Fear and Anxiety: Nipping it Young

Editor Paediatrics November 23, 2014

“Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.” Marie Curie A tiny tot stands at the threshold of the dental clinic, her palms tightly pressed against the ...Read More

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Sexual Maturity Rating – SMR in boys and girls

Editor Paediatrics August 2, 2014

In girls, the 1st visible sign of puberty and the hallmark of SMR 2 is the appearance of breast buds, between 8 and 12 yr of age. Menses typically begins 2-2.5 yr later, during SMR3-4 (median age, 12 yr; normal range, 9-16 yr). Less ...Read More

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Sickle Cell Disease: A Primer

Editor Medicine June 19, 2014

Background: Sickle cell disease (SCD) or sickle cell anemia (SCA) is a hemoglobinopathy wherein abnormal hemoglobin is produced. It was first noted by James Herrick a medical student of African descent in 1911, when he discovered sickle-shaped erythrocytes while examining a student’s blood. Linus ...Read More

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Thalassemia: Understanding the Disease

Editor General Health Issues, Medicine May 7, 2014

Thalassemia refers to a group of inherited disorders caused due to abnormal or inadequate production of the hemoglobin molecule, present in our red blood cells. Thalassemia is derived from two words – Thalassa means ‘the sea’ in Greek, which refers to the Mediterranean Sea; ...Read More

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Gullian Barre Syndrome – Post-infectious demyelinating polyneuropathy

Dr. Sujit Shrestha CNS March 6, 2014

Definition Guillain-Barre syndrome is a postinfectious polyneuropathy involving mainly motor but sometimes also sensory and autonomic nerves. Guillain-Barré syndrome is an acute demyelinating disorder of the peripheral nervous system that results from an aberrant immune response directed at peripheral nervesThe pathogenesis of GBS is believed ...Read More

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Maternal Rhesus Isoimmunization : Rh incompatibility

Sulabh Shrestha Gynae/Obstr January 3, 2014

Alloimmunization (Isoimmunisation) is defined as the antibody response to foreign antigen derived from different individual of the same species. Rh alloimmunization refers to the development antibodies to Rh D antigen. Antibodies may be produced to Rh antigens C,c,D,E, or e but only D is ...Read More

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Tetrabenazine – A forgotten drug for Dystonia

Editor Paediatrics October 26, 2013

An 8 year old girl presented to the pediatric ER with complaints of fever for 1 week, altered sensorium for 5 days and multiple episodes of generalized tonic clonic seizures for 4 days. She was a known case of neurocysticercosis for the last 6 ...Read More

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Chicken pox and its complications

Editor Paediatrics October 24, 2013

Varicella-zoster virus (VZV) Causes- primary, latent, and recurrent infections. Primary infection – Varicella (chickenpox) A lifelong latent infection of sensory ganglion neurons. Reactivation of the latent infection – Herpes zoster (shingles). Epidemiology Most children are infected by 15 yr of age, with fewer than 5% ...Read More

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