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Microbiology of Rabies Virus

Microbiology of Rabies Virus

Properties:

Belongs to genera “lyssavirus” of family “rhabdoviridae”
Bullet shaped
Nucleocapsid shows helical symmetry
ssRNA (single stranded RNA) virus
Outer lipoprotein envelope contains protruding hemagglutinating peplomer spikes

 
Street and Fixed virus Comparison:

Basis of difference
Street virus
Fixed virus

Definition
Freshly isolated viruses from natural human or animal infection that has not undergone any modification in the laboratory
Strains adapted to laboratory animals by several serial intracerebral passages in rabbits

Neurotropism
No
Yes

Incubation period
Long …

Rheumatoid Factor (RA Factor) and Its Diagnostic Importance

Rheumatoid Factor (RA Factor) and Its Diagnostic Importance

A presentaion on rheumatoid factor and its significance in diagnosis of rheumatoid arthritis by students of Kist Medical College

Objectives

To define Rheumatoid Factor .
To explain briefly its significance in the diagnosis of rheumatoid arthritis.

Rheumatoid factor

Rheumatoid factor (RF) is an autoantibody that is directed against organism’s own tissues, most relevant in rheumatoid arthritis.
An antibody against the Fc portion of IgG, which is …

Newer Antibiotics and their Uses – Review

Newer Antibiotics and their Uses – Review

FDA Approved Antibiotics which are marketed internationally. The problem of the antibiotic resistance has been over-viewed in the previous article. Here are the latest antibiotics in current use.

Oxazolidinones
In clinical use: Linezolid   In clinical trials: Radezolid, torezolid.
Effective against Organisms-
–gram-positive bacteria including MRSA, VRE and Streptococcus pneumoniae.
–Mycobacterium tuberculosis and Nocardia.
Linezolid- 1st to be approved this millenium
Indicated-
–VRE infections
–nosocomial and community-acquired pneumonia,
–skin and soft tissue infections.(SSTIs)

Bacteriostatic against …

Antibiotic Resistance and Newer antibiotics- An overview

Antibiotic Resistance and Newer antibiotics- An overview

The need for novel antibacterials is a desparation today because of increasing resistance to the older ones.Three classes of drug-resistant bacteria are a major cause of concern-
–Methicillin -resistantStaphylococcus aureus (MRSA),
–multidrug-resistant (MDR) and pan-drug-resistant (PDR) gram-negative bacteria, which include strains of Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa,
–MDR and  extensively-drug-resistant (XDR) strains of Mycobacterium tuberculosis (MDR-TB and XDR-TB).
Drug Resistance
•Multidrug resistance (MDR) bacteria – non-susceptibility …

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