Hereditary and Acquired Icthyosis Vulgaris
Background: The term ichthyosis is derived from the ancient Greek root ichthys, meaning fish. Hereditary ichthyosis vulgaris is an autosomal dominant genetic disorder first evident in early childhood. It is the most common form of ichthyosis, accounting for more than 95% of ichthyosis cases. Mutations in genes relating to skin barrier formation produce it. The […]
Read More
Acne- a disfiguring skin problem
A common skin problem of adolesence. Acne often disfigures and scar the skin to an extent that may cause depression and low self-confidience among people. • Acne is almost always seen in the teenage years • severity of disease differs per individuals • Peak severity is in the late teenage years But acne may persist into […]
Read More
Basic Terminologies in Dermatology
Description of Primary Skin Lesions Macule: A flat, colored lesion, <2 cm in diameter, not raised above the surface of the surrounding skin. A “freckle,” or ephelid, is a prototype pigmented macule. Patch: A large (>2 cm) flat lesion with a color different from the surrounding skin. This differs from a macule only in size. […]
Read More
Vitamin B3- Niacin Deficiency and Pellagra
Overview of Metabolism- Nicotinamide and nicotinic acid are covered under genre Niacin of which Nicotinamide is essential part of NAD and NADP. NAD and NADP are required in essential biochemical reaction of the body where they act as hydrogen acceptors and donor for many enzymes. Tryptophan is the substrate for this vitamin and it can […]
Read More
Penicillin Anaphylaxis : A Dreaded Drug Reaction
Penicillin or Beta lactam antibiotics are commonly associated with drug reactions which are immunologically mediated reactions. Why does penicillin anaphylaxis occur? The core structure Beta lactams consists of a reactive bicyclic B lactam ring that acts as a hapten by covalently binding to tissue carrier proteins. 95% of tissue bound penicillin is found to be […]
Read More
Psoriasis : Autoimmune disease of Skin
Psoriasis is a chronic, non-contagious, autoimmune disease involving keratinocyte proliferation along with inflammation and angiogenesis. It is sometimes associated with arthritis, myopathy, enteropathy, spondiolytic joint disease or AIDS. It frequently affects skin of elbows, knees, scalp, lumbosacral areas, intergluteal cleft and glans penis. It is characterized by pink to salmon colored psoriatic plaques covered and […]
Read More
Pemphigoids
PEMPHIGOIDS: disorder characterized by the eruption of multiple , tense bullae either over an erythematous or normal skin in an elderly patient. Age Old: ( 6-8 decades) General Health: Good Site : Flexural ( thigh, flexural of arms, axilla, groins) Mouth Ulcers: Rare Nature of Blisters: Large and tense over normal, urticarial or erythematous base. […]
Read MorePemphigus Vulgaris : A Vesiculobullous Disease
Overview: Derieved : Greek word pemphix meaning bubble. Named by Wichman in 1791. Pemphigus refers to a group of autoimmune blistering diseases of the skin and mucous membranes characterized by formation of flaccid bullae. . Pathophysiology Mediated by circulating autoantibodies directed against keratinocyte cell surfaces. Binding of IgG autoantibodies to keratinocyte desmosomes and to desmosome-free […]
Read More