Memory aid, educational, remembrance, techniques, information:
MULTI-DRUG REGIMEN IN LEPRSOY:
For Paucibacillary Leprosy (PBL):
Daily – Dapsone 100 mg (unsupervised)
Monthly – Rifampicin 600 mg (supervised)
Duration: 6 months
For Multibacillary Leprosy (MBL):
Daily – Dapsone 100 mg + Clofazamine 50 mg (unsupervised)
Monthly – Rifampicin 600 mg + Clofazamine 300 mg (supervised)
Duration: 1 yr
Formula : D / R for paucibacillary and DC / RC for multibacillary
Explanation: The denominator is the monthly drug to be taken. In case of MBL, note that the dose of Clofazamine is half the dose of other drug taken along with it ( 100 / 2 = 50, 600 / 2 = 300 ) in both the cases.
D FOR DAPSONE:
Mechanism of action (MOA) : inhibiting the synthesis of Dihydrofolic acid
Dosage of DapsONE is 100 mg/day – ONE hundreD mg per Day
Treatment of Dermatitis herpetiformis = Dapsone
Dapsone is used to treat many Dermatological conditions (A to Z : Acne, Behcets, Kaposi’s Sarcoma, Lupus erythematosus, Leprosy, Mycetoma, Pemphigus, Pyoderma gangrenosum, Rhinosporidiosis, spider bites, etc)
Side effects of Dapsone : blooD ( methemoglobinemia, hemolysis and anemia),Dapsone hypersensitivity syndrome ( Mainly Dermatological manifestations – Mononucleosis like rash, skin eruptions, etc), Hepatotoxity etc.
TREATMENT OF PATENT DUCTUS ARTERIOSUS:
Mnemonic: “come IN and CLOSE the door’
Indomethacin is used to close Patent Ductus Arteriosus.
SIDE EFFECTS OF ASPIRIN:
Peptic ulcer disease/ Phosphorylation-oxidation uncoupling/ PPH/ Platelet disaggregation/ Premature closure of PDA
Intestinal blood loss
DISEASE MODIFYING ANTI-RHEUMATOID DRUGS (DMARDs):
Hydroxycloroquine and choloroquinine
Auranofin and other gold compounds
INDICATION OF AURANOFIN & AUROTHIOGLUCOSE:
Acts Upon Rheumatoid
VITAMIN D METABOLISM:
UV rays from sun act on skin and convert Cholecalciferol (CC) >> 25 Hydroxy CC in liver >> 1,25 Di Hydroxy CC in kidney.
There are two hydroxylation reactions: 1st one in Liver and 2nd one in Kidney.
How to remember: You have 1 liver, 2 kidneys; So hydroxylation 1st reaction in your 1 liver and 2nd hydroxylation in 2 kidneys.
ANTIVIRAL DRUGS USE “vir” AT START, MIDDLE OR END:
Abacavir, Acyclovir, Amprenavir, Cidofovir, Denavir, Efavirenz, Indinavir, Invirase, Famciclovir, Ganciclovir, Norvir, Oseltamivir, Penciclovir, Ritonavir, Saquinavir, Valacyclovir, Viracept, Viramune, Zanamivir, Zovirax
INDICATIONS OF RIBAVIRIN:
a. RSV (Respiratory Synctial Virus)
b. Influenza B
c. Arenavirus (Lassa, Bolivian,etc.)
FOR FULL LIST OF MNEMONICS IN PHARMACOLOGY: