Exanthematous Illness

Exanthems – eruption of skin accompanied by inflammation.
Enanthems – eruption of mucous membrane.

Maculopapular rashes :

Measles
Rubella
Erythema Infectiosum
Roseola
Coxsackie
Echo virus
CMV and HBV
Erythema Multiforme due to Herpes virus, EBV, Adeno virus, Chlamydia, Salmonella, Mycobacteria, Histoplasma, Coccidiosis

Nodular rashes :

Fungal disease
Atypical Mycobacteria
Pseudomonas infection
Erythema Nodosum – Streptococcus, Mycobacteria, Yersinia, HCV, Sarcoidosis, Drugs and IBD

Diffuse erythematous with peeling or desquamation :

Scarlet fever
Toxic shock …

Paracetamol  Poisoning In Children:
Paracetamol  is a commonly prescribed drug in Medical practice. It is rapidly absorbed on oral intake and metabolized to sulph and glucoronide  group. Small amount is excreted in Urine.

Mechanism Of Toxiciy:

Paracetamol  is Metabolised to NABQI ( N- Acetyl –p-BenzoQuinimine) . Glutathione detoxifies it into Mercatopuric acid which is excreted in urine.
At Toxic Level, when >70 % …

Alternative names
Hutchinson-Gilford Progeria Syndrome (HGPS)
Hutchinson-Gilford Syndrome
Progeria Syndrome
Definition
Progeria is a rare and fatal congenital disorder marked by physical symptoms resembling that of aging but having early onset in childhood. The word “Progeria” is derived from the Greek word “Progerus” meaning “prematurely old”. It has a reported incidence of about 1 in 4 – 8 million newborns. It affects both sexes equally …

AN APPROACH TO A CHILD WITH WHEEZE

WHEEZES OR RONCHI:
Wheeze is a dry musical sound associated with airway narrowing.
The expiration is prolonged.
WHEEZING:
Common in infants and young children because of unique age specific anatomic and physiologic properties and gender specific intrinsic lung characteristics.
By year 1- 20 % children.
By 3 years- 33% children.
By 6 year- 50% children.
< 15% children are …