Microbiology of Rickettsia

General features: Small gram negative, aerobic, obligate intracellular (need CoA and NAD+)┬áthat infect mammals and arthropods. Non-motile, non-capsulated, non-sporing Contains both DNA and RNA Pleomorphic Microcapsule and slimelayer Main Species: R.prowazekii R.typhi R.ricketsii Orientia tsutsugamushi Pathogenesis: Virulence Factors: Endotoxin, Phospholipase A, Slime Layer Sites: Vascular system producing vasculitis Characteristic triad of symptoms: Fever, Headache, Rash […]

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