PEMPHIGOIDS:

disorder characterized by the eruption of multiple , tense bullae either over an erythematous or normal skin in an elderly patient.

Age Old: ( 6-8 decades)
General Health: Good
Site : Flexural ( thigh, flexural of arms, axilla, groins)
Mouth Ulcers: Rare
Nature of Blisters: Large and tense over normal, urticarial or erythematous base. Localised or widespread. Rupture and show tendency to heal.
Self limiting lesions
Antibodies: …

Overview:

Derieved : Greek word pemphix meaning bubble.
Named by Wichman in 1791.
Pemphigus refers to a group of autoimmune blistering diseases of the skin and mucous membranes characterized by formation of flaccid bullae.

.
Pathophysiology

Mediated by circulating autoantibodies directed against keratinocyte cell surfaces.
Binding of IgG autoantibodies to keratinocyte desmosomes and to desmosome-free areas of the keratinocyte cell membrane.
Loss of cell-cell adhesion,acantholysis..

PV antigen: …