Psoriasis is a chronic, non-contagious, autoimmune disease involving keratinocyte proliferation along with inflammation and angiogenesis. It is sometimes associated with arthritis, myopathy, enteropathy, spondiolytic joint disease or AIDS. It frequently affects skin of elbows, knees, scalp, lumbosacral areas, intergluteal cleft and glans penis. It is characterized by pink to salmon colored psoriatic plaques covered and demarcated by silver white …

PEMPHIGOIDS:

disorder characterized by the eruption of multiple , tense bullae either over an erythematous or normal skin in an elderly patient.

Age Old: ( 6-8 decades)
General Health: Good
Site : Flexural ( thigh, flexural of arms, axilla, groins)
Mouth Ulcers: Rare
Nature of Blisters: Large and tense over normal, urticarial or erythematous base. Localised or widespread. Rupture and show tendency to heal.
Self limiting lesions
Antibodies: …

Overview:

Derieved : Greek word pemphix meaning bubble.
Named by Wichman in 1791.
Pemphigus refers to a group of autoimmune blistering diseases of the skin and mucous membranes characterized by formation of flaccid bullae.

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Pathophysiology

Mediated by circulating autoantibodies directed against keratinocyte cell surfaces.
Binding of IgG autoantibodies to keratinocyte desmosomes and to desmosome-free areas of the keratinocyte cell membrane.
Loss of cell-cell adhesion,acantholysis..

PV antigen: …