Trisomy 21 or  Down Syndrome was first described by John Langdon Hayden Down a Physician ( 1828-1896 AD) in The London Hospital in 1866 AD.In 1959, Lejeune and Jacobs et al independently determined -trisomy 21 as cause of Down Syndrome.
March 21st every Year is Marked  as ” Down Syndrome Day” – 3rd month 21st
Karyotype-

Trisomy 21: 47 XX or XY …

Definition
The term fever of unknown origin (FUO) is best reserved for children with a fever documented by a health care provider and for which the cause could not be identified after 3 wk of evaluation as an outpatient or after 1 wk of evaluation in hospital.
Nelson Text Book 18thEdition
Ergönül O, Willke A, Azap A, et al. Revised definition of ‘fever of …

Cough is one of the most common presenting complain in children at Out-patient. Cough may be just a benign protective phenomenon , but at times it become troublesome . Cause of Cough Should be sought for even outside the respiratory system, like ears,abdomen etc.
CHRONIC COUGH
Cough  lasting for 4 weeks or more -CHEST January 2006
1.Inflammatory disorder of airway
Asthma & Loeffler’s syndrome, Tropical …

Anencephaly- Clinical features, pregnancy diagnosis, prevention and treatment.

Spina Bifida and anencephaly are most common Neural Tube Defect ( NTD) followed by encephalocele.  Anencephaly is a severe form of NTD, with 100% mortality. The baby is either born dead or is unfit for survival.
Anencephaly is a congenital birth defect (from the Latin congenitus, “born with”)
Incidence Of Anencephaly: …