Definition
The term fever of unknown origin (FUO) is best reserved for children with a fever documented by a health care provider and for which the cause could not be identified after 3 wk of evaluation as an outpatient or after 1 wk of evaluation in hospital.
Nelson Text Book 18thEdition
Ergönül O, Willke A, Azap A, et al. Revised definition of ‘fever of …

Cough is one of the most common presenting complain in children at Out-patient. Cough may be just a benign protective phenomenon , but at times it become troublesome . Cause of Cough Should be sought for even outside the respiratory system, like ears,abdomen etc.
CHRONIC COUGH
Cough  lasting for 4 weeks or more -CHEST January 2006
1.Inflammatory disorder of airway
Asthma & Loeffler’s syndrome, Tropical …

Trisomy 21 or  Down Syndrome was first described by John Langdon Hayden Down a Physician ( 1828-1896 AD) in The London Hospital in 1866 AD.In 1959, Lejeune and Jacobs et al independently determined -trisomy 21 as cause of Down Syndrome.
Karyotype-

Trisomy 21: 47 XX or XY +21 . Usually caused by an extra copy of Chromosome 21
Translocational …

Alternative names
Hutchinson-Gilford Progeria Syndrome (HGPS)
Hutchinson-Gilford Syndrome
Progeria Syndrome
Definition
Progeria is a rare and fatal congenital disorder marked by physical symptoms resembling that of aging but having early onset in childhood. The word “Progeria” is derived from the Greek word “Progerus” meaning “prematurely old”. It has a reported incidence of about 1 in 4 – 8 million newborns. It affects both sexes equally …