Definition
Guillain-Barre syndrome is a postinfectious polyneuropathy involving mainly motor but sometimes also sensory and autonomic nerves. Guillain-Barré syndrome is an acute demyelinating disorder of the peripheral nervous system that results from an aberrant immune response directed at peripheral nervesThe pathogenesis of GBS is believed to be an abnormal immune response to an antecedent event, most commonly an infection. (Nelson Textbook of …

Definition: Immunologic sequel of a previous group A beta hemolytic streptococcal infection of pharynx (not of the skin according to some researches). The rheumatogenic strains are M 1, 3, 5, 6, 14, 18, 19 and 24.
Pathogenesis:

Molecular mimicry
Affects brain, heart, joints, and skin
In genetically vulnerable host

Pathogenesis and morphology: Rheumatic fever and Rheumatic heart disease
Epidemiology:

Peak incidence: 5-15 years
Follows pharyngitis by 1 to …

Trisomy 21 or  Down Syndrome was first described by John Langdon Hayden Down a Physician ( 1828-1896 AD) in The London Hospital in 1866 AD.In 1959, Lejeune and Jacobs et al independently determined -trisomy 21 as cause of Down Syndrome.
March 21st every Year is Marked  as ” Down Syndrome Day” – 3rd month 21st
Karyotype-

Trisomy 21: 47 XX or XY …

What is ROP?
Retinopathy of prematurity (ROP) is a disease that primarily occurs in premature babies. It causes abnormal blood
vessels to grow in the retina, the layer of nerve tissue in the eye that enables us to see. This growth can cause
the retina to detach from the back of the eye, leading to blindness.
Originally described as “retrolental fibroplasia” in the early …

Definition
The term fever of unknown origin (FUO) is best reserved for children with a fever documented by a health care provider and for which the cause could not be identified after 3 wk of evaluation as an outpatient or after 1 wk of evaluation in hospital.
Nelson Text Book 18thEdition
Ergönül O, Willke A, Azap A, et al. Revised definition of ‘fever of …