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Gullian Barre Syndrome – Post-infectious demyelinating polyneuropathy

Gullian Barre Syndrome – Post-infectious demyelinating polyneuropathy

Definition
Guillain-Barre syndrome is a postinfectious polyneuropathy involving mainly motor but sometimes also sensory and autonomic nerves. Guillain-Barré syndrome is an acute demyelinating disorder of the peripheral nervous system that results from an aberrant immune response directed at peripheral nervesThe pathogenesis of GBS is believed to be an abnormal immune response to an antecedent event, most commonly an infection. (Nelson Textbook of …

Tetrabenazine – A forgotten drug for Dystonia

Tetrabenazine – A forgotten drug for Dystonia

An 8 year old girl presented to the pediatric ER with complaints of fever for 1 week, altered sensorium for 5 days and multiple episodes of generalized tonic clonic seizures for 4 days. She was a known case of neurocysticercosis for the last 6 years, had been under antiepileptic therapy (carbamazepine and phenytoin) for 3 years and was discontinued after …

Chicken pox and its complications

Chicken pox and its complications

Varicella-zoster virus (VZV)

Causes-  primary, latent, and recurrent infections.
Primary infection – Varicella (chickenpox)
A lifelong latent infection of sensory ganglion neurons.
Reactivation of the latent infection – Herpes zoster (shingles).

Epidemiology
Most children are infected by 15 yr of age, with fewer than 5% of adults remaining susceptible.Within households, transmission of VZV to susceptible individuals occurs at a rate of 65-86%
Infectivity : 24-48 hr before the rash …

Chronic or Recurrent Respiratory Symptoms in Children – An Approach

Chronic or Recurrent Respiratory Symptoms in Children – An Approach

Common Recurrent or Persistent Respiratory Symptoms -

Cough
Wheeze
Stridor
 Persistent Lung Infiltrates #

Evaluation of chronic respiratory symptoms can be difficult  because –

Symptoms  – close succession of unrelated ARTI
Symptoms may have Single pathophysiologic process.
Lack of specific diagnostic tests.
Parental anxiety – pressure for quick therapeutic relief.

Approach to Diagnosis and Treatment
•Points to remember
–Symptoms – minor problem or life threatening process.
–Determine – most likely pathogenic mechanism.
–Simplest effective …

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