An 8 year old girl presented to the pediatric ER with complaints of fever for 1 week, altered sensorium for 5 days and multiple episodes of generalized tonic clonic seizures for 4 days. She was a known case of neurocysticercosis for the last 6 years, had been under antiepileptic therapy (carbamazepine and phenytoin) for 3 years and was discontinued after …
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Varicella-zoster virus (VZV)
Causes- primary, latent, and recurrent infections.
Primary infection – Varicella (chickenpox)
A lifelong latent infection of sensory ganglion neurons.
Reactivation of the latent infection – Herpes zoster (shingles).
Most children are infected by 15 yr of age, with fewer than 5% of adults remaining susceptible.Within households, transmission of VZV to susceptible individuals occurs at a rate of 65-86%
Infectivity : 24-48 hr before the rash …
Common Recurrent or Persistent Respiratory Symptoms -
Persistent Lung Infiltrates #
Evaluation of chronic respiratory symptoms can be difficult because –
Symptoms – close succession of unrelated ARTI
Symptoms may have Single pathophysiologic process.
Lack of specific diagnostic tests.
Parental anxiety – pressure for quick therapeutic relief.
Approach to Diagnosis and Treatment
•Points to remember
–Symptoms – minor problem or life threatening process.
–Determine – most likely pathogenic mechanism.
–Simplest effective …
Guillain-Barre syndrome is a postinfectious polyneuropathy involving mainly motor but sometimes also sensory and autonomic nerves. Guillain-Barré syndrome is an acute demyelinating disorder of the peripheral nervous system that results from an aberrant immune response directed at peripheral nervesThe pathogenesis of GBS is believed to be an abnormal immune response to an antecedent event, most commonly an infection. (Nelson Textbook of …