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Auscultatory gap in hypertension

Auscultatory gap in hypertension

Sometimes during manual blood pressure measurement by auscultatory method, after a few initial tapping sounds, no sound is heard for a variable duration and then the sounds are heard again. This period when no sound is heard is called as auscultatory gap.
Korotkoff sounds:
When the cuff pressure is great enough to close the artery during part of the arterial pressure cycle, …

Unfractioned Heparin and Low Molecular Weight Heparins

Unfractioned Heparin and Low Molecular Weight Heparins

Unfractioned Heparin-
Unfractioned Heparin- is derived from  porcine intestinal mucosa or bovine lung tissue. UFH catalyzises that inactivation of thrombin and factor Xa by inhibiting Anti-thrombin III.  At usual dose it prolongs TT and aPTT and has a minimal effect on PT/INR.
Benefits of UFH-

1. The effect of UFH normalizes within hours of discontinuation
2. It is reversible with Protamine Sulphate.
3. Can be …

Acute Coronary Syndrome or ACS

Acute Coronary Syndrome or ACS

Acute Coronary Syndrome (ACS) consists of spectrum of illness which includes:

Unstable angina
NSTEMI or Acute Non Q web MI
Acute MI

Conventionally ACS refers to UA and NSTEMI
Pathophysiology:

Plaque rupture → Platelet adhesion to expose collagen in coronary arteries → Activation of platelets → Platelet aggregation → thrombus formation → ACS
Coronary spasm → Decreased Myocardial circulation → ACS

Stable and Unstable Plaque are the 2 …

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